Sb. Dent et al., Soy protein intake by perimenopausal women does not affect circulating lipids and lipoproteins or coagulation and fibrinolytic factors, J NUTR, 131(9), 2001, pp. 2280-2287
Soy protein favorably alters serum lipids and lipoproteins in hypercholeste
rolemic individuals, thereby reducing cardiovascular disease risk. The prim
ary purpose was to determine the effect of soy protein (40 g/d) on circulat
ing lipids and lipoproteins or coagulation and fibrinolytic factors in norm
ocholesterolemic and mildly hypercholesterolemic perimenopausal women. We a
lso determined the contribution of coagulation and fibrinolytic and other f
actors (e.g., body size and composition; serum estrogens, ferritin, iron; d
ietary intake) to lipid profiles. Subjects were randomly assigned to treatm
ent: isoflavone-rich soy (n = 24), isoflavone-poor soy (n = 24), or whey co
ntrol (n = 21) protein. We measured circulating lipids and lipoproteins at
baseline, wk 12 and wk 24, and coagulation/fibrinolytic factors at baseline
and wk 24. Coagulation and fibrinolytic factors were not adversely affecte
d by treatment. Treatment did not alter lipid profiles in mildly hyperchole
sterolemic (n = 30) or in all subjects combined. Time significantly (P < 0.
001) affected serum total cholesterol, triacylglycerol, LDL cholesterol and
HDL cholesterol concentrations. We could not attribute changes over time t
o various factors, but at baseline accounted for 57% of the variability in
HDL cholesterol (P less than or equal to 0.0001) and for 50% in the total t
o HDL cholesterol ratio (P less than or equal to 0.0001). Dietary vitamin E
and % energy from fat had positive effects, whereas plasma plasminogen act
ivator inhibitor-1, fibrinogen, body weight and serum ferritin had negative
effects on HDL and total to HDL cholesterol. Isoflavone-rich or isoflavone
-poor soy protein had no effect on lipid profiles or coagulation and fibrin
olytic factors, whereas the effect of time suggested that the hormonal mili
eu during the menopausal transition may have overridden any detectable trea
tment effect on lipids. The relationship between coagulation factors and se
rum lipids should be examined further as indices of cardiovascular disease
risk in midlife women.