Application of the transformed Potts-Guy equation to in vivo human skin data

Data developed by Wenkers and Lippold for the flux of 10 nonsteroidal anti- inflammatory drugs from light mineral oil (MO) through human skin in vivo h as been analyzed using the transformed Potts-Guy equation. The analysis sho ws that the flux is dependent not only on the solubility in MO (S-MO), but also on the solubility in acidic water (S-AQ). This dependence of flux on S -AQ shows that the previously reported dependence of flux on S-AQ from in v itro experiments using hairless mouse skin is not an artifact of the in vit ro experiments but is due to a characteristic of the skin barrier. Further inspection of the equations used by Wenkers and Lippold in their analyses o f their data shows that the equations are variations of the transformed Pot ts-Guy equation. (C) 2001 Wiley-Liss, Inc. and the American Pharmaceutical Association.