This case history describes the history of the Center for Urban Epidemiolog
ical Studies (CUES), an urban research center based in New York City. Betwe
en 1996 and 1999, CUES was transformed from an institution that worked with
the medical schools of the region to a center seeking to define a new prac
tice of community-based participatory research (CBPR). The report summarize
s how and why CUES has changed, identifies its main accomplishments and cha
llenges, and discusses some of the lessons learned to date. It illustrates
how the Principles of CBPR have influenced the development of CUES. The cas
e history suggests that it is possible for an organization to transform its
elf from a researcher-driven orientation toward a more participatory model.
The early history also demonstrates that it is possible to engage communit
y organizations and activists in an ongoing effort to study and address com
plex urban health problems such as asthma, substance abuse, and infectious
diseases. Finally, the report illustrates that CBPR is a process that evolv
es in response to specific situational factors.