We introduce two definitions of an averaged system for a time-varying ordin
ary differential equation with exogenous disturbances ("strong average" and
"weak average"). The class of systems for which the strong average exists
is shown to be strictly smaller than the class of systems for which the wea
k average exists. It is shown that input-to-state stability (ISS) of the st
rong average of a system implies uniform semi-global practical ISS of the a
ctual system, This result generalizes the result of [TPA] which states that
global asymptotic stability of the averaged system implies uniform semi-gl
obal practical stability of the actual system. On the other hand, we illust
rate by an example that ISS of the weak average of a system does not necess
arily imply uniform semi-global practical ISS of the actual system. However
, ISS of the weak average of a system does imply a weaker semi-global pract
ical "ISS-like" property for the actual system when the disturbances w are
absolutely continuous and w, w is an element of L-x, ISS of the weak averag
e of a system is shown to be useful in a stability analysis of time-varying
cascaded systems.