Motor sequencing deficits in schizophrenia: A comparison with Parkinson's disease

Motor abnormalities occur in schizophrenia (SZ) and may arise from striatal dysfunction. This study examined whether the pattern of performance on sim ple and complex motor abilities. in SZ was similar to that of patients with Parkinson's disease (PD). Quantitative tests of speeded movement and motor and cognitive sequencing were used to assess 25 SZ, 16 PD, and 84 normal c ontrols (NCs). Sequencing performance was also examined with motor rigidity taken into account. Compared with the NC group, the SZ and PD groups were impaired on measures of motor rigidity and motor sequencing. With rigidity accounted for, the SZ group was significantly more impaired than the PD gro up on motor sequencing; cognitive and motor processes contributed to the mo tor deficit. Cognitive sequencing performance predicted motor sequencing pe rformance in PD but not SZ. Although both SZ and PD resulted in significant motor and cognitive sequencing deficits, the pattern and correlates of the se deficits differ, suggesting that the affected neural systems underlying motor deficits in SZ are different from those involved in PD.