Ablative surgery for tumors of the globe and its adnexal structures is freq
uently the cause of major orbitofacial deformity. Radiotherapy compounds th
e problem because it suppresses skeletal growth in the growing patient and
induces a contraction of the remaining soft tissues in the orbit. Goals for
reconstruction in these patients include the restoration of orbital struct
ures to allow the fitting of an ocular prosthesis and the correction of dis
torted orbitofacial relationships. The authors present a series of 53 patie
nts (mean age, 29 years; 28 male) who were treated over the past 18 years b
y composite reconstruction of the post-tumoral anophthalmic orbit. The foll
ow-up ranged from 5 months to 18 years (mean, 7.75 years). Four patients we
re treated primarily (immediate reconstruction after tumor ablation), and 4
9 were treated secondarily (mean oncological follow-up since ablative surge
ry, 14.8 years). Twenty-eight patients underwent orbital enucleation (inclu
ding three bilateral cases), 23 underwent orbital exenteration, and two und
erwent evisceration. Forty-two patients received radiotherapy, including 20
enucleation patients, 15 exenteration patients, and seven others in whom d
etails of primary therapy were incomplete. A staged reconstruction was unde
rtaken in each case; it considered, in turn, the bony orbital volume (orbit
al remodeling and cranial bone grafts), orbital contents (implant, temporal
is muscle transposition, cranial bone grafts, and dermafat grafts), conjunc
tival sac (mucosal and skin grafts), ocular prosthesis, eyelids (local flap
s and skin grafts), and additional procedures to restore orbitofacial symme
try. The authors conclude that the long-term results of post-tumoral orbita
l reconstruction are favorable, and they particularly recommend the use of
autogenous tissues in irradiated orbits.