Objective: To obtain population-based information on the characteristi
cs of persons who were not receiving chemoprophylaxis against Pneumocy
stis carinii pneumonia (PCP) by examining the use of primary and secon
dary PCP prophylaxis among San Francisco residents whose AIDS-defining
opportunistic illness was PCP in 1993. Design: Retrospective medical
record review. Setting: Medical charts were obtained From San Francisc
o hospitals and outpatient facilities at which AIDS patients received
their initial AIDS diagnosis. Participants: San Francisco residents wh
ose AIDS-defining opportunistic illness was PCP in 1993. Main outcome
measures: Use of primary and secondary PCP prophylaxis. Results: Of th
e 326 eligible patients, 35% received primary PCP prophylaxis. Nonwhit
es were significantly less likely to have received primary PCP prophyl
axis than white patients [22 versus 40%, respectively; odds ratio (OR)
, 0.49195% confidence intervals (CI), 0.28-0.87]. Uninsured individual
s were also less likely to have received primary PCP prophylaxis than
those with insurance (18 versus 41%, OR, 0.35; 95% Cl, 0.17-0.73). The
sociodemographic characteristics of patients who did and did not rece
ive secondary PCP prophylaxis did not differ significantly. The most f
requently cited reasons for not receiving primary PCP prophylaxis were
that patients were unaware of their infection with HIV or were not re
ceiving regular medical care. Conclusions: Barriers to receipt of PCP
prophylaxis exist and are resulting in cases of preventable disease an
d unnecessary medical costs. Interventions to increase counseling, tes
ting, and referral to medical care for pet-sons at high risk for HIV i
nfection are needed.