The authors examined early psychopathology as a predictor of trajectories o
f drug use from ages 13-18 years. Six years of annual data were analyzed fo
r 506 boys using a mixed effects polynomial growth curve model. They tested
whether distinct measures of psychopathology and behavioral problems (i.e,
, attention-deficit/hyperactivity disorder, oppositional defiant disorder,
conduct disorder, depression, and violence) assessed in early adolescence c
ould prospectively predict level and change in alcohol and marijuana use. H
igher levels of all of the types of psychopathology predicted higher levels
of alcohol use, and higher levels of attention-deficit/hyperactivity disor
der, conduct disorder, and violence predicted higher levels of marijuana us
e. Only conduct disorder predicted linear growth in alcohol use, and none o
f the measures predicted growth in marijuana use. The results suggest that
drug use prevention programs should target youths with early symptoms of ps
ychopathology.