Ea. Palombo et al., SEQUENCE OF THE VP7 GENE OF AN ATYPICAL HUMAN ROTAVIRUS - EVIDENCE FOR GENETIC AND ANTIGENIC DRIFT, DNA sequence, 7(5), 1997, pp. 307-311
The nucleotide sequence of the gene encoding the outer capsid glycopro
tein, VP7, isolated from a reassortant human rotavirus, M3014, was det
ermined. The deduced amino acid sequence exhibited significant identit
y to the VP7 from a standard strain belonging to serotype G4, although
the antigenic regions of the M3014 VP7 resembled sequences from both
serotype G4 and G9 viruses. However, reactivity with G4 or G9 serotype
-specific monoclonal antibodies was not observed. We suggest that the
M3014 VP7 was derived from sequential mutation of a G4-like progenitor
gene resulting In a protein with novel antigenic properties.