A gene expression map for Caenorhabditis elegans

Citation
Sk. Kim et al., A gene expression map for Caenorhabditis elegans, SCIENCE, 293(5537), 2001, pp. 2087-2092
Citations number
31
Categorie Soggetti
Multidisciplinary,Multidisciplinary,Multidisciplinary
Journal title
SCIENCE
ISSN journal
00368075 → ACNP
Volume
293
Issue
5537
Year of publication
2001
Pages
2087 - 2092
Database
ISI
SICI code
0036-8075(20010914)293:5537<2087:AGEMFC>2.0.ZU;2-S
Abstract
We have assembled data from Caenorhabditis elegans DNA microarray experimen ts involving many growth conditions, developmental stages, and varieties of mutants. Co-regulated genes were grouped together and visualized in a thre e-dimensional expression map that displays correlations of gene expression profiles as distances in two dimensions and gene density in the third dimen sion. The gene expression map can be used as a gene discovery toot to ident ify genes that are co-regulated with known sets of genes (such as heat shoc k, growth control genes, germ line genes, and so forth) or to uncover previ ously unknown genetic functions (such as genomic instability in mates and s perm caused by specific transposons).