1-ALPHA,25-DIHYDROXYVITAMIN D-3 INDUCES VERY-LOW-DENSITY LIPOPROTEIN RECEPTOR MESSENGER-RNA EXPRESSION IN HL-60 CELLS IN ASSOCIATION WITH MONOCYTIC DIFFERENTIATION

Authors
KOHNO M TAKAHASHI S OIDA K SUZUKI J TAMAI T YAMAMOTO T NAKAI T
Citation
M. Kohno et al., 1-ALPHA,25-DIHYDROXYVITAMIN D-3 INDUCES VERY-LOW-DENSITY LIPOPROTEIN RECEPTOR MESSENGER-RNA EXPRESSION IN HL-60 CELLS IN ASSOCIATION WITH MONOCYTIC DIFFERENTIATION, Atherosclerosis, 133(1), 1997, pp. 45-49
Citations number
20
Categorie Soggetti
Peripheal Vascular Diseas
Journal title
Atherosclerosis → ACNP
ISSN journal
00219150
Volume
133
Issue
1
Year of publication
1997
Pages
45 - 49
Database
ISI
SICI code
0021-9150(1997)133:1<45:1DIVLR>2.0.ZU;2-0
Abstract
Expression of VLDL receptor mRNA during differentiation of HL-60 cells was investigated by Northern analysis. The expression induced in 1 al pha,25-dihydroxyvitamin D-3 (1 alpha,25(OH)(2)D-3)-treated cells was 3 times that in untreated cells, while LDL receptor mRNA expression was unchanged. VLDL receptor mRNA levels were not changed in macrophages caused to differentiate from HL-60 cells by treatment with phorbol 12- myristate 13-adetate (PMA). Treatment of sarcoma cells which possess t he vitamin D receptor (MG-63 cell line) with 1 alpha,25(OH)(2)D-3 did not affect VLDL receptor- mRNA levels. Therefore, 1 alpha,25(OH)(2)D-3 induces VLDL receptor mRNA in HL-60 cells through differentiation-dep endent mechanisms. (C) 1997 Elsevier Science Ireland Ltd.