Influence of positive end-expiratory pressure on intracranial pressure andcerebral perfusion pressure in patients with acute stroke

Background and Purpose-We undertook this study to evaluate the influence of positive end-expiratory pressure (PEEP). on intracranial pressure (ICP) an d cerebral perfusion pressure (CPP) in patients with acute stroke. Methods-A total of 20 ventilated patients of a neurological intensive care unit were examined under a protocol entailing variation of PEEP to 4, 8, 12 , and 4 mm Hg; mean arterial blood pressure (MAP), ICP, heart rate, and mea n velocity of the middle cerebral arteries (V-m MCA) were recorded. Results-CPP significantly changed depending on the various PEEP levels. No significant differences in remaining parameters were evident. Three distinc t reaction patterns of the parameters monitored were observed: (1) All para meters remained stable through the various PEEP levels (15 patients, 40 exa minations). (2) Increase in PEEP resulted in a significant decrease of MAP, while V-m MCA remained unchanged, indicating an intact cerebral autoregula tion. A slight (statistically insignificant) increase in ICP, which was sig nificantly related to the MAP changes, was evident (7 patients, 16 examinat ions). (3) Increase in PEEP resulted in a decrease of MAP and V-m MCA, ICP remained unchanged or demonstrated a slight decline (3 patients, 6 examinat ions). Conclusions-PEEP increase up to 12 min Hg does not significantly influence ICP. The observed marked changes in CPP are mediated through the MAP. Thus, PEEP application should be safe, provided that MAP is maintained.