Novel biphenol phosphoramidite ligands for the enantioselective copper catalyzed conjugate addition of dialkyl zincs

Authors
Alexakis, A Rosset, S Allamand, J March, S Guillen, F Benhaim, C
Citation
A. Alexakis et al., Novel biphenol phosphoramidite ligands for the enantioselective copper catalyzed conjugate addition of dialkyl zincs, SYNLETT, (9), 2001, pp. 1375-1378
Citations number
43
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
9
Year of publication
2001
Pages
1375 - 1378
Database
ISI
SICI code
0936-5214(200109):9<1375:NBPLFT>2.0.ZU;2-R
Abstract
Phosphoramidite ligands, based on a chiral amine and atropoisomerically fle xible biphenols, induce high enantioselectivities (ee's up to 98%) in the c opper-catalyzed conjugate addition of dialkyl zinc reagents to a variety of Michael acceptors.