Synthesis of SB-214857 using copper catalysed amination of arylbromides with L-aspartic acid

Authors
Clement, JB Hayes, JF Sheldrake, HM Sheldrake, PW Wells, AS
Citation
Jb. Clement et al., Synthesis of SB-214857 using copper catalysed amination of arylbromides with L-aspartic acid, SYNLETT, (9), 2001, pp. 1423-1427
Citations number
16
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
9
Year of publication
2001
Pages
1423 - 1427
Database
ISI
SICI code
0936-5214(200109):9<1423:SOSUCC>2.0.ZU;2-N
Abstract
An efficient synthesis of a 1,4-benzodiazepine was accomplished using coppe r catalysed amination of an arylbromide with the soluble bis-tetrabutylammo nium salt of L-aspartic acid as a key step.