An improved synthesis of enantiopure beta-amino acids

Authors
Cimarelli, C Palmieri, G Volpini, E
Citation
C. Cimarelli et al., An improved synthesis of enantiopure beta-amino acids, SYN COMMUN, 31(19), 2001, pp. 2943-2953
Citations number
48
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
31
Issue
19
Year of publication
2001
Pages
2943 - 2953
Database
ISI
SICI code
0039-7911(2001)31:19<2943:AISOEB>2.0.ZU;2-B
Abstract
An improved method for the preparation of both the enantiopure beta -amino acids is presented. The diastereomer benzyl beta -amino esters, obtained by stereoselective reduction of beta -enamino esters, were separated and hydr ogenolyzed to the free enantiopure beta -amino acids.