Regioselective palladium-catalyzed cross-coupling reactions in the synthesis of novel 2,3-disubstituted thiophene derivatives

Authors
Pereira, R Iglesias, B de Lera, AR
Citation
R. Pereira et al., Regioselective palladium-catalyzed cross-coupling reactions in the synthesis of novel 2,3-disubstituted thiophene derivatives, TETRAHEDRON, 57(37), 2001, pp. 7871-7881
Citations number
59
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
37
Year of publication
2001
Pages
7871 - 7881
Database
ISI
SICI code
0040-4020(20010910)57:37<7871:RPCRIT>2.0.ZU;2-I
Abstract
A reactivity optimization study of the palladium-catalyzed cross-coupling r eactions of 2,3-dibromothiophene and organometallic reagents has been condu cted. Regioselective coupling at the C2 position, accomplished most notably by Suzuki coupling, was combined with a Stille reaction at C3 using Fu's m odification, to afford the 2,3-disubstituted thiophene derivatives. (C) 200 1 Elsevier Science Ltd. All rights reserved.