A new palladium catalyst system for the cyanation of aryl chlorides

Authors
Sundermeier, M Zapf, A Beller, M Sans, J
Citation
M. Sundermeier et al., A new palladium catalyst system for the cyanation of aryl chlorides, TETRAHEDR L, 42(38), 2001, pp. 6707-6710
Citations number
39
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
38
Year of publication
2001
Pages
6707 - 6710
Database
ISI
SICI code
0040-4039(20010917)42:38<6707:ANPCSF>2.0.ZU;2-M
Abstract
The influence of reaction conditions and additives on the palladium-catalyz ed cyanation of aryl chlorides with potassium cyanide has been investigated . Successful cyanation of aryl chlorides is observed in the presence of pal ladium catalysts using potassium cyanide. It is shown that the combination of a 1,5-bis(diphenylphosphino)pentane ligand and the addition of N,N,N',N' -tetramethylethylenediamine (TMEDA) as a co-catalyst are the key factors in obtaining the corresponding aryl nitriles with improved catalyst productiv ities and selectivities. (C) 2001 Elsevier Science Ltd. All rights reserved .