De novo initiation of viral RNA-Dependent RNA synthesis

Authors
Kao, CC Singh, P Ecker, DJ
Citation
Cc. Kao et al., De novo initiation of viral RNA-Dependent RNA synthesis, VIROLOGY, 287(2), 2001, pp. 251-260
Citations number
124
Categorie Soggetti
Microbiology
Journal title
VIROLOGY
ISSN journal
00426822 → ACNP
Volume
287
Issue
2
Year of publication
2001
Pages
251 - 260
Database
ISI
SICI code
0042-6822(20010901)287:2<251:DNIOVR>2.0.ZU;2-V
Abstract
RNA viruses use several initiation strategies to ensure that their RNAs are synthesized in appropriate amounts, have correct termini, and can be trans lated efficiently. Many viruses with genomes of single-stranded positive-, negative-, and double-stranded RNA initiate RNA synthesis by a de novo (pri mer-independent) mechanism. This review summarizes biochemical features and variations of de novo initiation in viral RNA replication. (C) 2001 Academ ic Press.