Therapeutic intensive seizure analysis (TISA) in presurgical evaluation ofLosigamone

Objective - The new method TISA was used to evaluate Losigamone efficacy. M ethods - Sixteen patients with pharmacoresistant partial seizures undergoin g presurgical evaluation were randomized in this double-blind, placebo-con trolled, parallel-group Losigamone monotherapy study under continuous video -EEG monitoring. Duration (in s, of each seizure and each ictal sign), inte nsity (grade zero to three), N/24 h (number of seizures and ictal signs per 24 h), D/24 h (seconds per 24 h covered by seizures and ictal signs) and s eizure free intervals were recorded. Results - A total of 246 seizures were intensively analyzed. The duration and intensity of all seizures improved more in the active treatment group than in the placebo group. There was a s tatistically significant superiority in the duration of the seizure free in terval in the Losigamone group. Ictal signs such as oro-alimentary automati sms and fumbling were improved during Losigamone treatment. Conclusion - Lo sigamone has a preferred inhibitory effect on propagated epileptic activity . TISA is a sensitive method for evaluation of the selective effects of AED s.