Inhibition of regrowth of prostatic glandular cells by epristeride

AIM: To evaluate the ability of epristeride to inhibit the prostatic glandu lar regrowth. METHODS: Normal rats were castrated. Testosterone was injecte d to induce the regrowth of glandular cells. HE staining was performed. The height of the glandular epithelium and the acinar luminal areas were deter mined, and dihydrotestosterone ( DHT) was detected by immunohistochemistry. RESULTS : Both the height and the acinar luminal areas were reduced by 48 % and 55 % in epristeride-treated group compared with control group respect ively. The staining of DHT was comparatively strong in the control group. A fter 30-d of treatment, it tamed much weaker. CONCLUSION: The regrowth of g landular cells was inhibited by epristeride via declining of the DHT concen tration in the rat prostate.