THE USE OF RADICAL DECARBOXYLATION IN THE PREPARATION OF 1-METHYLCARBAPENEM ANTIBIOTIC PRECURSORS FROM D-GLUCOSAMINE

Authors
ANAYA J BARTON DHR CABALLERO MC GERO SD GRANDE M LASO NM HERNANDO JIM
Citation
J. Anaya et al., THE USE OF RADICAL DECARBOXYLATION IN THE PREPARATION OF 1-METHYLCARBAPENEM ANTIBIOTIC PRECURSORS FROM D-GLUCOSAMINE, Tetrahedron : asymmetry, 5(11), 1994, pp. 2137-2140
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
5
Issue
11
Year of publication
1994
Pages
2137 - 2140
Database
ISI
SICI code
0957-4166(1994)5:11<2137:TUORDI>2.0.ZU;2-7
Abstract
The stereocontrolled synthesis of optically active 1-methylcarbapenams has been performed by radical cyclization and radical decarboxylation . 1,3,4-Trisubstituted-2-azetidinones, prepared by the Staudinger reac tion with D-glucosamine as chiral auxiliary and sorbic acid were used as starting materials.