Localization of the gene for the intermediate form of Charcot-Marie-Tooth to chromosome 10q24.1-q25.1

Intermediate Charcot-Marie-Tooth neuropathy (CMT) is an inherited sensory m otor neuropathy characterized by motor median nerve conduction velocities o f 25-45 m/s. We performed a genomewide search in an Italian family with aut osomal dominant intermediate CMT and mapped the locus on chromosome 10q. An alysis of key recombinants maps the gene for autosomal dominant intermediat e CMT to a 10.7-Mb interval on chromosome 10q24.1-q25.1, between simple tan dem repeat markers D10S1709 and D10S1795.