Vascular cell adhesion molecule-1 as a biochemical marker of left ventricular mass in the patients with hypertension

Plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1), vascu lar adhesion molecule-1 (sVCAM-1), and E-selectin were measured in 80 outpa tients with uncomplicated essential hypertension. Although the levels of E- selectin and sICAM-1 were similar between the patients with and without lef t ventricular (LV) hypertrophy, sVCAM-1 level was significantly elevated in the patients with LV hypertrophy (759.7 +/- 154.6 ng/mL nu 984.4 +/- 240.6 ng/mL, P < .0001). The LV mass normalized to body surface area or height w ere significantly correlated with sVCAM-1 (r = 0.615, P < .0001 and r = 0.5 71, P < .0001, respectively). These results indicate that a soluble adhesio n molecule is correlated with LV mass in uncomplicated essential hypertensi ve patients. (C) 2001 American Journal of Hypertension, Ltd.