Citation
Jj. Mcsharry et al., Susceptibilities of human cytomegalovirus clinical isolates to BAY38-4766,BAY43-9695, and ganciclovir, ANTIM AG CH, 45(10), 2001, pp. 2925-2927
Citations number
16
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804
→ ACNP
Volume
45
Issue
10
Year of publication
2001
Pages
2925 - 2927
Database
ISI
SICI code
0066-4804(200110)45:10<2925:SOHCCI>2.0.ZU;2-5
Abstract
BAY38-4766 and BAY43-9695 are nonnucleosidic compounds with activities agai
nst human cytomegalovirus (HCMV). Two phenotypic assays were used to determ
ine the drug susceptibilities of 36 HCMV clinical isolates to the BAY compo
unds and ganciclovir. Using either assay, both BAY compounds at a concentra
tion of approximately 1 muM inhibited the replication of all 36 HCMV clinic
al isolates, including 11 ganciclovir-resistant clinical isolates, by 50%.