Effects of new quinolones on transepithelial electrical potential difference of tracheal mucosa in vivo

Authors
Kanoh, S Tamaoki, J Kondo, M Nagano, Y Nagai, A
Citation
S. Kanoh et al., Effects of new quinolones on transepithelial electrical potential difference of tracheal mucosa in vivo, ANTIM AG CH, 45(10), 2001, pp. 2928-2930
Citations number
16
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
10
Year of publication
2001
Pages
2928 - 2930
Database
ISI
SICI code
0066-4804(200110)45:10<2928:EONQOT>2.0.ZU;2-Y
Abstract
Superfusion of canine tracheal mucosa with 100 mug each of grepafloxacin an d ciprofloxacin per ml reduced the electrical transepithelial potential dif ference in vivo by more than 50%. This effect was dose dependent, specific for new quinolones, and inhibited by Cl channel blockers, indicating that n ew quinolones attenuate Cl secretion across the airway epithelium.