IN-VITRO STUDIES OF 2 5-NITROIMIDAZOLE DERIVATIVES

This paper reports the findings obtained using two new compounds belon ging to the 5-nitroimidazole family: sulphuridazole (V1) and sulphonid azole (V2). We first assessed their antimicrobial activity on Clostrid ia spp, and then extended the study to Gram-positive and Gram-negative aerobic microorganisms and to Candida albicans. Their MICs were compa red with those of metronidazole. The findings show that the antibacter ial and antimycotic activity of sulphonidazole is greater than that of sulphuridazole, while metronidazole is not active against any aerobic organism. it also emerges that the NO, group is indispensable for all the microorganisms assayed and that sulphuridazole and sulphonidazole are the first two 5-nitroimidazoles active against C. albicans. The r edox potentials of the 5-nitroimidozoles studied suggest that their ac tion mechanism is mainly based on redox processes.