Effect of acetophenone derived Mannich bases on cellular glutathione levelin jurkat cells - A possible mechanism of action

Authors
Gul, M Gul, HI Vepsalainen, J Erciyas, E Hanninen, O
Citation
M. Gul et al., Effect of acetophenone derived Mannich bases on cellular glutathione levelin jurkat cells - A possible mechanism of action, ARZNEI-FOR, 51(8), 2001, pp. 679-682
Citations number
18
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
ISSN journal
00044172 → ACNP
Volume
51
Issue
8
Year of publication
2001
Pages
679 - 682
Database
ISI
SICI code
0004-4172(2001)51:8<679:EOADMB>2.0.ZU;2-L
Abstract
The effect of the acetophenone derived mono Mannich bases 1-3 and his Manni ch base 7 (his derivative of compound 3) on cellular glutathione level was investigated in Jurkat cells. The cells were exposed to the compounds in ph osphate buffered saline for I h in 37 degreesC with gentle shaking and then glutathione level was measured. Especially, mono Mannich base 3 and its hi s derivative 7 decreased total glutathione level in a dose-dependent manner . The results provide further support for the thiol alkylation mechanism ex plaining the cytotoxic activity of Mannich bases.