THE PHARMACOKINETICS OF INTRAVENOUS CIPROFLOXACIN 400 MG 12 HOURLY INPATIENTS WITH SEVERE SEPSIS - THE EFFECT OF RENAL-FUNCTION AND INTRAABDOMINAL DISEASE

Serum concentrations of ciprofloxacin were reviewed in 22 patients giv en ciprofloxacin 400 mg intravenously 12 hourly for severe infection. No dosage modifications were made in patients with renal impairment, P atients who had either bowel or liver pathology in addition to renal f ailure had significantly higher serum concentrations than ail other pa tients. Dosage reduction of ciprofloxacin in patients with severe seps is and impaired renal function is not required unless they have co-exi stent intra-abdominal disease.