Molecular model for the binary complex of uropepsin and pepstatin

Authors
de Azevedo, WF Canduri, F Fadel, V Teodoro, LGVL Hial, V Gomes, RAS
Citation
Wf. De Azevedo et al., Molecular model for the binary complex of uropepsin and pepstatin, BIOC BIOP R, 287(1), 2001, pp. 277-281
Citations number
23
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN journal
0006291X → ACNP
Volume
287
Issue
1
Year of publication
2001
Pages
277 - 281
Database
ISI
SICI code
0006-291X(20010914)287:1<277:MMFTBC>2.0.ZU;2-F
Abstract
The three-dimensional structure of human uropepsin complexed with pepstatin has been modelled using human pepsin as a template. Uropepsin is an aspart ic proteinase from the urine, produced in the form of pepsinogen A in the g astric mucosa. The structure is bilobal, consisting of two predominantly be ta -sheet lobes which, as observed in other aspartic proteinases, are relat ed by a pseudo twofold axis. A structural comparison between binary complex es of pepsin:pepstatin and uropepsin:pepstatin is discussed. (C) 2001 Acade mic Press.