Mammaglobin is found in breast tissue as a complex with BU101

The mammaglobin gene has been shown to be preferentially expressed in breas t tissue. Few genes match its specificity. Mammaglobin has generated much i nterest, and studies are ongoing to develop diagnostic tests for breast can cer based on the detection of mammaglobin. While searching the Incyte Genom ics Lifeseq database for tissue-specific markers, we observed a second secr etoglobin, BU101, also known as lipophilin B. We report here that mammaglob in, in breast tissue, is found as a complex with BU101. The complex was iso lated from breast cancer tissue and was characterized as the biologically r elevant form of mammaglobin.