Activation and inhibition of succinate-dependent Ca2+ transport in liver mitochondria during adaptation

Succinate-dependent Ca2+ accumulation was investigated in rat liver mitocho ndria and in operation biopsies of patients under states either with preval ence of adrenergic influences (administration of activating doses of adrena line, acute phase of immobilization stress, initial period after allogenic transplantation, and acute phase of myocardial infarction) or with prevalen ce of the reciprocal mediator acetylcholine (late period after transplantat ion, chronic ulcer disease of stomach and duodenum). Adrenaline prevalence leads to increase of succinate-dependent ATP synthesis and Ca2+ accumulatio n, which is due to known activation of succinate oxidation. However, togeth er with activation, inhibition of these processes was revealed. The inhibit ion phase prevails under chronic pathology. Therefore, reciprocal regulatio n of succinate oxidation and succinate-dependent Ca2+ transport in mitochon dria occurs in the body in the course of adaptation. The reciprocal regulat ion of mitochondrial processes is considered as a mechanism of reciprocal r egulation of physiological functions.