A novel multilocus genotyping assay to identify genetic predictors of stroke in sickle cell anaemia

Authors
Hoppe, C Cheng, S Grow, M Silbergleit, A Klitz, W Trachtenberg, E Erlich, H Vichinsky, E Styles, L
Citation
C. Hoppe et al., A novel multilocus genotyping assay to identify genetic predictors of stroke in sickle cell anaemia, BR J HAEM, 114(3), 2001, pp. 718-720
Citations number
10
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
BRITISH JOURNAL OF HAEMATOLOGY
ISSN journal
00071048 → ACNP
Volume
114
Issue
3
Year of publication
2001
Pages
718 - 720
Database
ISI
SICI code
0007-1048(200109)114:3<718:ANMGAT>2.0.ZU;2-#
Abstract
We describe a novel multilocus genotyping assay permitting simultaneous ide ntification of 60 candidate markers for stroke in sickle cell anaemia (SCA) . Based on cerebral magnetic resonance imaging (MRI), 69 patients were divi ded into stroke and control groups. The variant allele, CBS 278thr, showed protection from stroke, whereas the apoE3 allele showed a trend towards ass ociation with increased stroke risk. Several other variant alleles [TNF alp ha (-308)A, CETP (-628)A, apoCIII (-641)A] showed a trend towards significa nt associations with stroke risk. These preliminary results on a small grou p of patients suggest that a multilocus genotyping assay may be valuable in identifying genes that increase the risk of stroke in SCA.