An hsr on chromosome 7 was shown to be an insertion of four copies of the 11q23 MLL gene region in an HIV-related lymphoma

A 45-year-old male with AIDS presented with a cecal diffuse large B-cell ly mphoma. Cytogenetic and flourescence in situ hybridization (FISH) studies r evealed a complex karyotype with multiple aberrations that included a trans location, t(8;14) involving MYC on chromosome 14. This is specific to B-cel l lymphomas. There were also frequently observed secondary changes such as chromosome I rearrangement leading to trisomy of Iq and loss of tp53 from t he deleted chromosome 17. A unique secondary abnormality was an hsr on chro mosome 7, which by FISH and SKY investigations was shown to originate from chromosome 11 involving 4 copies of the MLL gene region. (C) 2001 Elsevier Science Inc. All rights reseserved.