Considered a rare disease during the 19th century lung cancer became the mo
st virulent and lethal cause of cancer mortality by the end of the 20th cen
tury. In this paper, lung cancer and its treatment are addressed within the
social, cultural, economic, and political context of the last century. Bec
ause lung cancer is related to the consumption of cigarettes, the battles o
ver tobacco control are highlighted. Four time periods are addressed: the e
arly years (1900-1930), beginning of the epidemic (1930-1960), defining the
problem (1960-1980), and expanding options (1980-1990s). Although improvem
ents have been made in science and technology, attempts at finding curative
treatments have met with little success. Smoking cessation and efforts to
control tobacco (especially, among children and adolescents) remain the mos
t important factors if the incidence of lung cancer is to be curtailed in t
he future. Providing care to individuals with the illness is a current chal
lenge. Research examining the efficacy, of treatments and their effect on s
urvival, health-related quality of life, and cost outcomes is essential and
can be best achieved through the efforts of multidisciplinary teams.