D. Konopinska, INSECT NEUROPETIDE PROCTOLIN AND ITS ANALOGS - AN OVERVIEW OF THE PRESENT LITERATURE, The journal of peptide research, 49(6), 1997, pp. 457-466
In the present paper, the literature describing synthetic, biological
and conformational studies on the insect neuropeptide proctolin (H-Arg
-Tyr-Leu-Pro-Thr-OH) and its analogues is summarized. The paper covers
proctolin and its 80 analogues modified in positions 1-5, a cycloanal
ogue and analogues with a truncated or elongated peptide chain. These
peptides were bioassayed by different methods, e.g. studies of myotrop
ic activities in several insect species in vitro and behaviour in rats
in vivo. Based on these data structure-activity relationships are dis
cussed. (C) Munksgaard 1997.