INSECT NEUROPETIDE PROCTOLIN AND ITS ANALOGS - AN OVERVIEW OF THE PRESENT LITERATURE

In the present paper, the literature describing synthetic, biological and conformational studies on the insect neuropeptide proctolin (H-Arg -Tyr-Leu-Pro-Thr-OH) and its analogues is summarized. The paper covers proctolin and its 80 analogues modified in positions 1-5, a cycloanal ogue and analogues with a truncated or elongated peptide chain. These peptides were bioassayed by different methods, e.g. studies of myotrop ic activities in several insect species in vitro and behaviour in rats in vivo. Based on these data structure-activity relationships are dis cussed. (C) Munksgaard 1997.