Cranial infantile myofibromatosis: report of three cases

Background: Infantile myofibromatosis is a proliferative disorder of infanc y and early childhood characterized by the development of single or multipl e nodular lesions arising from cutaneous or subcutaneous tissue, muscle, bo ne or visceral organs. In approximately one-third of cases, this myofibrobl astic proliferation involves the head and neck region. Case report: In this paper we report on three cases of cranial infantile my ofibromatosis in infants. The clinical presentation and the deceptive histo pathological features can make diagnosis difficult. Conclusion: The significance of recognizing this entity is stressed, since its indolent clinical behavior might prevent diagnosis.