Treatment of hepatic failure with artificial liver support system

Objective To assess the effectiveness of artificial liver support system (A LSS) treatment in patients with hepatic failure. Methods 235 cases of hepatic failure were treated with ALSS in our hospital . All data were analyzed by SPSS. The effectiveness of ALSS treatment was c ompared according to different stages ( i.e., early, middle and end stages) . Results 108 patients survived after therapy of ALSS. After each ALSS treatm ent, the liver function of these patients was greatly improved, the serum e ndotoxin and HBV-DNA concentrations were significantly decreased, and the s erum concentration of aromatic amino acids (AAA) such as methionine decreas ed while the ratio of branched chain amino acids and aromatic amino acids ( BCAA/AAA ratio) increased; patients treated with ALSS in the early or middl e stages of disease had much higher survival rates than patients in the end stage of disease. Conclusion ALSS is a reliable therapy for advanced liver diseases and treat ment at early or middle stages is appropriate.