Electrochemical behavior of adriamycin at a cobalt ion implantation modified electrode

With Co/GCE in 0.005 mol Tris/L/0.05 mol/L NaCl solution (pH 7.1), a sensit ive reductive peak of amgcin (ADM) was obtained by the linear scan voltamme try. The peak potential is -0.62 V (vs. SCE). The peak current is proportio nal to the concentration of ADM. The electrochemical behavior of the system was studied by the linear-sweep and cyclic voltammetry. The experiments sh owed that the reduction at Co/GCE is a quasi-reversible process with adsorp tion. According to Laviron's theory, the electrode reaction rate constant k (0) and the electron transfer coefficient alpha are determined to be 2.15 s (-1) and 0.62, respectively. The composition of the surface, valence state of elements and depth distribution of elements on the surfaces of Co/GCE we re determined by the X-ray photoelectron spectroscopy and Auger electron sp ectroscopy. The experiments showed that Co was surely implanted into the su rface of GCE. The implanted Co element in the form of Co-C catalyzed the re duction of ADM.