Research progress of magnetic resonance imaging contrast agents

Magnetic resonance imaging (MRI) is a clinical diagnostic modality, which h as become popular in hospitals around the world. Approximately 30% of MRI e xams include the use of contrast agents. The research progress of the param agnetic resonance imaging contrast agents was described briefly. Three impo rtant approaches in the soluble paramagnetic resonance imaging contrast age nts design including nonionic, tissue-specific and macromolecular contrast agents were investigated. In addition, the problems in the research and dev elopment in future were discussed.