Minimizing potential resistance: The molecular view

The major contribution of molecular biology to the study of antibiotic resi stance has been the elucidation of nearly all biochemical mechanisms of res istance and the routes for dissemination of genetic information among bacte ria. In this review, we consider the potential contribution of molecular bi ology to counteracting the evolution of resistant bacteria. In particular, we emphasize the fact that fundamental approaches have had direct practical effects on minimizing potential resistance: by improving interpretation of resistance phenotypes, by providing more adequate human therapy, by foster ing more prudent use of antibiotics, and by allowing the rational design of new drugs that evade existing resistance mechanisms or address unexploited targets.