An overview of the role and inter-relationship of epidermal growth factor receptor, cyclin D and retinoblastoma protein on the carcinogenesis of squamous cell carcinoma of the larynx

Citation
Ma. Rafferty et al., An overview of the role and inter-relationship of epidermal growth factor receptor, cyclin D and retinoblastoma protein on the carcinogenesis of squamous cell carcinoma of the larynx, CLIN OTOLAR, 26(4), 2001, pp. 317-320
Citations number
28
Categorie Soggetti
Otolaryngology
Journal title
CLINICAL OTOLARYNGOLOGY
ISSN journal
03077772 → ACNP
Volume
26
Issue
4
Year of publication
2001
Pages
317 - 320
Database
ISI
SICI code
0307-7772(200108)26:4<317:AOOTRA>2.0.ZU;2-9
Abstract
Recent developments in both molecular and cellular biology have improved th e understanding of the tumorigenesis of laryngeal squamous cell carcinoma. Loco-regional recurrence of this condition still poses a significant oncolo gical management dilemma for a subset of these tumours. Therefore, the poss ibility that specific tumour characteristics (demonstrable by immunohistoch emical and molecular biological study) may aid the clinician in choosing th e optimal treatment for a specific tumour holds great promise. This article concentrates on the role and inter-relationship of epidermal growth factor receptor status on the function of cyclin D, and how this is related to th e presence of retinoblastoma protein. A review of recent studies evaluating these markers, the potential clinical utility of these findings and the po ssible directions for further study are discussed.