The present study recorded activities of magnetoencephalography (MEG) to th
e presentation of cards, and to the presentation of feedback signals in 12
normal subjects while they performed the Wisconsin Card Sorting Test (WCST)
, to observe temporal and spatial processing during the task, The MEG respo
nses were compared between two different conditions in the presentation bot
h of cards and of feedback signals: the cards proceeded by the first wrong
[W1st(C)] and by the 4th correct feedback signals [C4th(C)]; and the feedba
ck of the first wrong [W1st(FB)] and the 4th correct signals [C4th(FB)]. A
multi-dipole model, brain electric source analysis (BESA), was used to expl
ore the dipole sources responsible for the MEG activities, We found that ME
G activity differences between the W1st(C) and the C4th(C) condition occurr
ed in the period of 190-220 ms (M190 and M200), and 300-440 ms (M300 and M3
70) mainly at the supramarginal gyrus, the dorsolateral prefrontal, and the
middle and inferior frontal gyrus. MEG differences between the W1st(FB) an
d the C4th(FB) condition occurred 460-640 ms (M460) after the presentation
of the feedback signals, with the activation of the dorsolateral prefrontal
cortex and the middle frontal cortex. No significant location differences
were found between the frontal responses (M370) of the W1st(C) and M460 of
the W1st(FB). Our results proved that the WCST task activates a broad front
al area and the parieto-frontal network across time streaming. Both shiftin
g attention to the wrong feedback and enhanced visual working memory to the
sorting shifting condition of the card presentation occur in the same area
s at different time points, (C) 2001 Elsevier Science B.V. All rights reser
ved.