Farnesyl protein transferase inhibition: A novel approach to anti-tumor therapy. The discovery and development of SCH 66336

Authors
Ganguly, AK Doll, RJ Girijavallabhan, VM
Citation
Ak. Ganguly et al., Farnesyl protein transferase inhibition: A novel approach to anti-tumor therapy. The discovery and development of SCH 66336, CURR MED CH, 8(12), 2001, pp. 1419-1436
Citations number
42
Categorie Soggetti
Pharmacology & Toxicology
Journal title
CURRENT MEDICINAL CHEMISTRY
ISSN journal
09298673 → ACNP
Volume
8
Issue
12
Year of publication
2001
Pages
1419 - 1436
Database
ISI
SICI code
0929-8673(200110)8:12<1419:FPTIAN>2.0.ZU;2-#
Abstract
Farnesyl protein transferase (FPT) inhibition is an interesting and promisi ng approach to non-cytotoxic anticancer therapy. Research in this area has resulted in several orally active compounds that are currently in clinical evaluation. This review focuses on FPT inhibitors in clinical trials and co ncentrates on the benzocycloheptapyridine class, with details on the discov ery and development of SCH 66336, currently in Phase II clinical trials.