Pathogenesis and treatment of Ph+ leukemia: recent insights from mouse models

Several methods to model human Ph+ leukemia in laboratory mice are availabl e, including propagation of BCR/ABL-expressing cells in mice, xenotransplan tation of primary Ph+ leukemia cells into immunodeficient mice, BCR/ABL tra nsgenic mice, and BCR/ABL retroviral bone marrow transduction and transplan tation. Recent studies in these different model systems have yielded import ant advances in our knowledge of the pathogenesis and therapy of human chro nic myeloid leukemia and Ph+ B-lymphoblastic leukemia, and are the subject of this review. (C) 2001 Lippincott Williams & Wilkins, Inc.