In humans and most other mammals, the antidiuretic hormone (ADH) is a nonap
eptide often referred to as arginine vasopressin (AVP). It is produced by l
arge neurons that originate in the supraoptic and paraventricular nucleus o
f the hypothalamus and project through the pituitary stalk to terminate on
capillary plexuses scattered throughout the posterior pituitary. These plex
uses drain into the systemic circulation by way of the cavernous sinus and
superior vena cava.