Apoptosis in the hydropic cochlea of guinea pigs following immune reactionof the endolymphatic sac: immunohistochemical analysis

Citation
K. Watanabe et al., Apoptosis in the hydropic cochlea of guinea pigs following immune reactionof the endolymphatic sac: immunohistochemical analysis, EUR ARCH OT, 258(6), 2001, pp. 296-299
Citations number
20
Categorie Soggetti
Otolaryngology
Journal title
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
ISSN journal
09374477 → ACNP
Volume
258
Issue
6
Year of publication
2001
Pages
296 - 299
Database
ISI
SICI code
0937-4477(200108)258:6<296:AITHCO>2.0.ZU;2-M
Abstract
Apoptotic change in the cochlea was studied by immunohistochemistry after t he injection of keyhole limpet haemocyanin (KLH) into the right endolymphat ic sac of guinea pigs. Apoptosis was examined with the specific antibody to single-stranded DNA (ssDNA). Endolymphatic hydrops became evident in the c ochlea 1 day after the injection of KLH (n = 6). Increased ssDNA expression could be detected in the spiral ligament and the stria vascularis. The tem poral bones in the control group did not show any ssDNA immunoreactivity (n = 6). Apoptosis is the process of the cell death. Our findings imply that apoptotic changes are involved in endolymphatic hydrops. These phenomena co uld lead to cochlear dysfunction as seen in endolymphatic hydrops.