Birth of a healthy girl after ICSI with ejaculated spermatozoa from a man with non-mosaic Klinefelter's syndrome

Klinefelter's syndrome is a major contributor to male infertility. Recent r eports of births after ICSI with especially testicular spermatozoa from inf ertile men with this syndrome are promising. The birth of a healthy girl af ter ICSI treatment with ejaculated spermatozoa from a man with non-mosaic K linefelter's syndrome is reported. The nonmosaic karyotype was confirmed by chromosome analysis of both peripheral blood leukocytes and fibroblasts fr om a skin biopsy. In conclusion, in a very few cases, men with apparently n on-mosaic Klinefelter's syndrome have ejaculated spermatozoa that can resul t in a birth of a healthy child following ICSI.