Cryotherapy has been used for destruction of endobronchial tumors. Cryother
apy works by its cytotoxic effect, by freezing the tissue, thus causing tis
sue death. Cryotherapy can be performed by rigid bronchoscopy under general
anesthesia. It can also be performed by fiberoptic bronchoscopy under seda
tion and local anesthesia. The indications for cryotherapy are similar to t
hose for endobronchial laser or electrocautery. The purpose of cryotherapy
is essentially to ablate the endobronchial tumor. Cryotherapy has also been
used for treatment of carcinoma in situ as well as benign endobronchial tu
mors. The advantages which cryotherapy provides is safety not only for the
operator, but also for the patient. The major counterindication for cryothe
rapy is a patient with impending respiratory failure. In certain situations
cryotherapy has also shown to have a beneficial effect in conjunction with
radiation therapy as well as chemotherapy. Cryotherapy offers an alternati
ve for endobronchial tumor ablation with significant safety as well as bein
g relatively inexpensive.