HORMONAL RESPONSE DURING A FENFLURAMINE-ASSOCIATED PANIC ATTACK

Secretion curves for prolactin, cortisol, TSH, and GH from a 37-year o ld woman with dysthymia and panic disorder with agoraphobia were deter mined one day prior to (day I), and during a panic attack (day II) ass ociated with an oral dose of 60 mg dl-fenfluramine, a drug known to in crease anticipatory anxiety. The increased cortisol secretion observed is discussed in relation to the hormonal correlates of anxiety and th e possible role of depression, dl-fenfluramine, and serotonergic recep tor sensitivity.