AMLODIPINE VS NIFEDIPINE-RETARD - EVALUATION OF EFFICACY AND TOLERABILITY USING AMBULATORY BLOOD-PRESSURE MONITORING

Two groups of 30 outpatients took part in a 3-month study designed to compare the efficacy and tolerability of the dihydropyridine calcium a ntagonists amlodipine and nifedipine retard in patients with mild to m oderate essential hypertension. Data from 24-hour ambulatory blood pre ssure monitoring confirmed that both drugs produced good blood pressur e control, although more significant and persistent reductions were ob served in amlodipine recipients. This superiority may be due to the su stained plasma concentrations produced by this drug. Patients treated with amlodipine also experienced fewer adverse events than the nifedip ine group.